Shadowbox selected as a COOL company

April 26, 2021  |  Greg Stein  | 


Shadowbox, the leading innovator of healthcare automation solutions, is excited to announce that San Diego CONNECT selected the technology startup as a 2021 “Cool Company” from a pool of nearly 200 applicants. CONNECT is a non-profit supporting the Southern California innovation community by providing access to investors, mentors, and education. Each year, a panel of finance and subject matter experts selects companies with the greatest potential to transform their industries and raise venture capital funding.

Shadowbox invented a new and patented solution for securely automating the exchange of sensitive data at the click of a button.  The solution accelerates the transfer of accurate, complete, and compliant patient health information, improving care while reducing errors and costs across the healthcare spectrum.

Selected as a 2021 Cool Company by CONNECT, Shadowbox deploys new tech to tackle the $350B healthcare integration challenge.

“I’ve been following Shadowbox since the beginning,” said CONNECT CEO Mike Krenn.“ They are tackling one of the world’s most complex problems with a winning combination of innovative technology, focused go-to-market strategy, and effective leadership. This is exactly the kind of company that attracts venture capital investment. Shadowbox exemplifies the Cool Company ethos to highlight the very best in our community.”

“The pandemic proved that incumbent healthcare integration technologies are completely broken and ineffective.  When 90% of Doctors still use fax machines to order lab tests, the urgency for Shadowbox to introduce a disruptive integration solution has never been more crucial,” said Shadowbox CEO Gregory A. Stein. “Our solution is so efficient we were recently recruited into a Seegene-led consortium to serve as the integration partner on the US Government’s $10B K-8 COVID testing initiative now out for bid. There is simply no other technology that can monitor test capacity across hundreds of labs and direct each lab’s excess capacity in real-time to wherever it is needed most.”

“We are extremely grateful to Mike Krenn and CONNECT, not only for recognizing Shadowbox as a technology success story but also for his unwavering commitment to creating an innovation economy in San Diego by bringing venture capital dollars to our city,” noted Shadowbox CFO Beth Crocker. “We look to Mike as a mentor and advisor, who often gives us valuable advice and support.”

Shadowbox is a ground-breaking, patented, no-code integration and automation platform. By powering a browser with security, AI, and user-driven cross-application connections, Shadowbox offers instant integration at the click of a button.

For more information, see

Connect is a community non-profit organization passionate about helping tech and life sciences entrepreneurs build great companies. Connect serves entrepreneurs throughout their growth journey with a suite of curated programs aimed to help companies grow, gain access to capital, and scale. The national venture capital community is annually presented with ‘Cool Companies,’ San Diego’s top-performing startups, selected neutrally by our elite community of VCs, angel investors, entrepreneurs, executives, market influencers, and community leaders. We help innovative companies thrive so they can make a meaningful impact on the economic development of the region and together create a world-class tech ecosystem.

Seegene is the global leader in multiplex molecular diagnostics, tirelessly pursuing innovation and new challenges to build a better future for humanity. Seegene’s high multiplex real-time PCR technologies enable simultaneous detection of multiple infections to drive precise, timely, and affordable diagnosis and care.

Greg brings diverse experience, a vast network, and over 30 years of leadership to his role at Shadowbox. Most recently, Greg was Vice President of Strategic and Community Affairs and an original investor with Millennium Health, where he helped grow the company to more than 1,500 employees and $1.8BN in enterprise value. Prior to Millennium, Greg served in numerous leadership roles such as CFO of a start-up in the defense and action sports space; EVP of a political economics start-up division in the macroeconomic firm founded by Dr. Arthur Laffer, the world-renowned economist; VP of a start-up in a sell-side investment bank; and CEO of a start-up consortium of defense contractors delivering software to the US Air Force and Navy.

Additional articles by Greg Stein